Second, the authors indicated that their study suggested that synovial membrane inflammation plays a role early in ROA. The result of this subgroup analysis is also worthy of expectation. Since K-L grade is largely driven by the presence of OSP, particularly between grades 0 and 2, OSP and joint space narrowing assessed individually according to the Osteoarthritis Research Society International atlas 7 would be better. First, the authors indicated that pro-inflammatory cytokines contribute to OA pathogenesis by increasing cartilage degradation. In addition to all the above, there are some other issues that need to be mentioned. The result of this sensitivity analysis is worthy of expectation. 3–6 We are also very curious about whether the causal relationship between synovitis and development of early ROA (K-L grade 1 or 2) still remained. However, there were some other studies that regarded patients with a K-L grade of 1 or 2 as having early ROA. In addition, ROA was defined as Kellgren–Lawrence (K-L) grade ≤2. We very much look forward to the causal relationship between synovitis and development of ROA, which were both evaluated by MRI. So it is hard to say that the sequence of synovitis and ROA was not because of unequal diagnostic method. Of the 21 ACLR knees with MRI-defined tibiofemoral OA, 18 (86%) did not have radiographic tibiofemoral OA, which means that MRI is also useful in diagnosing early OA before radiographic changes occur. A new study conducted by Culvenor et al 2 reported that of all the knee osteophytes (OSPs) presented on MRI (67%), just over one-third (26%) were visible on radiographs following anterior cruciate ligament reconstruction (ACLR). However, we have no idea why the authors did not use MRI to evaluate the ROA. We agree with the authors’ point of view that the best imaging method to identify synovial inflammation is by MRI, and MRI is useful to investigate early ‘preclinical’ disease before radiographic changes occur. However, there are some worthwhile issues that need to be explored.Įffusion-synovitis and Hoffa-synovitis were assessed by MRI, while ROA was evaluated by a posterior–anterior radiograph. The findings supported the potential role of targeted therapies for synovitis in the prevention of knee osteoarthritis (OA). We really appreciate the work which was done by the authors.

This nested case–control study suggested that effusion-synovitis and Hoffa-synovitis strongly predicted the development of incident ROA. We read with deep interest the article by Atukorala et al 1 aimed at determining if synovitis precedes the development of radiographic knee osteoarthritis (ROA).

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